To address challenges, Creative Diagnostics has introduced an alternative to hard-to-find human disease state IgM plasma. These human hybrid IgM control Mab materials cover a wide range of diseases, including CMV, HSV, MeV, MuV, RuV, M. pneumoniae, T. gondii, and VZV. The monoclonal antibodies are produced in transgenic mice that express the human IgM heavy chain constant region. The antibodies are then concentrated and added to an IgG-removed and defatted human serum matrix to ensure the final product closely resembles IgM-positive human plasma in the natural disease state. Rigorous testing in ELISA and bead-based applications has shown that the products behave in an almost identical manner to their natural counterparts.

For example, Creative Diagnostics offers Anti-CMV monoclonal antibody (DMAB-CLS25048) to formulate calibrators and controls for CMV IgM assays. Cytomegalovirus (CMV) is widespread, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. In addition, Creative Diagnostics provides the Anti-HSV-1/2 monoclonal antibody(DMAB-CLS25049) to prepare calibrators and controls for the HSV-1/2 IgM assay. Herpes simplex virus (HSV), also known as herpes, is a common infection that causes painful blisters or sores. It spreads primarily through skin-to-skin contact, and it is treatable but not curable.

Manufactured under ISO 13485 standards, this new portfolio of antibodies can ensure exceptional quality and reproducibility. Their lot-to-lot consistency and performance will empower laboratory researchers to enhance the accuracy and reliability of their diagnostic tests. Creative Diagnostics can now provide clients a stable, high-performance, and ethically sourced supply of control materials.

For more information about the Human Hybrid IgM Control Monoclonal Antibodies or other other research tools, please visit https://www.creative-diagnostics.com/new-human-hybrid-igm-control-monoclonal-antibody.htm.